The Secret of Proteins Interaction

Proteins are large biomolecules that act in various ways to maintain cellular structure, mobility, energy generation and metabolism. Different types of proteins are in charge of every biological function life requires. To this end, proteins must be correctly folded, to gain the 3D structure that enables them optimal performance. Moreover, interactions between proteins, which take place on specific residues, regulate their activation, structure and subcellular localization. Proper binding is crucial both for the activity of the protein complexes and to prevent cellular dysfunction and diseases. Moreover, knowing the exact residue on which the bond takes place may enable the development of targeted treatments. In an article published in Computational and Structural Biotechnology Journal, Prof. Hanoch Senderowitz and Prof. Ron Unger analyze protein-protein interaction sites at the molecular level. They present a new level of understanding of this field, identifying prominent motifs that may be used in the future as possible components for protein engineering.