Prof. Ayal Hendel
CV
Prof. Ayal Hendel is a world-renowned lecturer and researcher in the field of genetic editing. His research focuses on the use of CRISPR technologies for genetic editing with the aim of developing genetic therapies for genetic diseases and cancer. Prof. Hendel's contribution to the field is reflected, among other things, by the fact that dozens of his articles have been cited thousands of times in the scientific literature.
In recent years, Prof. Hendel's laboratory has also played a key role in the development of a computational tool called CRISPECTOR, which is used for CRISPR-based analysis of trial results, allowing scientists around the world to develop more effective and safer genetic therapies.
Prof. Hendel also received a large grant from a research consortium funded by the European Union to investigate gene therapy strategies for sickle cell anemia. As part of this project, Prof. Hendel's laboratory will lead a work group that will test genetic editing accuracy in CRISPR-based medical uses.
In addition to his research activities, Prof. Hendel is a member of the American Society of Gene & Cell Therapy (ASGCT), the European Society of Gene & Cell Therapy (ESGCT), and the executive committee of the Israel Society of Gene and Cell Therapy (ISGCT); he also chairs the CRISPR-IL scientific committee and is a member of the editorial board of the Rare Diseases and Orphan Drugs Journal.
Prof. Hendel holds a BSc degree in life sciences from the Hebrew University and an MA degree and a PhD degree in biochemistry from the Weizmann Institute of Science. After receiving his PhD degree, Prof. Hendel began his postdoctoral research at the Weizmann Institute of Science, from which he transferred to Stanford University in California. Since returning to Israel in 2016, Porf. Hendel has been a senior lecturer at the Mina and Everard Goodman Faculty of Life Sciences at Bar-Ilan University.
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Grants, Awards, and Scholarships
2023-2025 – Jeffrey Modell Foundation (JMF) grant for investigating the potential of a CRISPR-based method for genetically repairing a gene involved in SCID
2022-2027 – Horizon Europe Consortium grant for the study of CRISPR-based genetic therapies for sickle cell anemia
2022-2024 – Joint grant from Sheba Medical Center and Bar-Ilan University for the development of CRISPR-based cellular therapies
2020-2023 – Grant from the Israel Innovation Authority as part of the Magnet - CRISPR-IL Consortium Program
2019-2023 – Israel Science Foundation - Israel Precision Medicine Program (ISF-IPMP) grant for the study of personalized diagnosis, genetic characterization, and gene therapy for congenital immunodeficiency diseases
2019-2023 – Israel Science Foundation (ISF) grant for investigating a CRISPR-based method for genetically repairing a gene that causes SCID
2018-2019 – Israel Innovation Authority grant for developing a platform that identifies off-target CRISPR edits
2017-2020 – Ministry of Science, Technology, and Space grant for investigating genetic therapy for the Ataxia Telangiectasia syndrome (Louis-Bar syndrome, a severe hereditary disease)
2017-2023 – European Research Council (ERC) grant for investigating CRISPR-mediated genetic therapy for Severe Combined Immunodeficiency (SCID)
2015 – Academic scholarship from the Stanford Children's Health Research Institute (CHRI)
2014 – Travel scholarship from the Stanford Cardiovascular Institute (CVI)
2013 – Postdoctoral research scholarship from the Myotonic Dystrophy Foundation
2012 – Dean's postdoctoral research scholarship, Stanford School of Medicine
2011 – Travel scholarship from the Northwest Genomic Engineering Consortium (NGEC)
2010 – Scholarship for participation in the European Society of Human Genetics conference from the Genetic Society of Israel (GSI)
2008 – Scholarship for participation in the Gordon Research Conference (GRC)
Other Positions
2017-2019 Member of the Young Researchers of Natural Sciences forum, the Israel Academy of Sciences and Humanities
Research Proposal Reviewer
Reviewing research proposals applying for Israeli and international research grants
Editor of Scientific Journals
Co-Editor, Frontiers in Genome Editing
Editorial Board Member, Rare Disease and Orphan Drugs Journal
Reviewing Editor, Frontiers in Immunology
Research Reviewer in Scientific Journals
Journal of Visualized Experiments
Frontiers in Immunology
Molecular Therapy- Methods & Clinical Development
The CRISPR Journal
Scientific Reports
Stem Cell Reports
Molecular Therapy
Nature Biotechnology
Nucleic Acid Research
Gene Therapy
Frontiers in Genome Editing
Emerging topics in life sciences
PLOS One
Nature Communication
List of Patents
- Nuclease-mediated genome editing of primary cells and enrichment thereof. 2016. Inventors: Daniel P. Dever, Rasmus O. Bak, Ayal Hendel, Waracharee Srifa, Matthew H. Porteus. WO2017053729A1
- Chemically mediated guide RNAs for CRISPR/CAS-mediated gene regulation. 2016. Inventors: Matthew H. Porteus, Ayal Hendel, Joe Clark, Rasmus O. Bak. U.S. WO2016164356A1
- Methods and systems for determining effects of nucleic acid editing. 2021. Inventors: Ayal Hendel, Zohar Yakhini, Ido Amit. PCT/IL2021/050539
Last Updated Date : 02/05/2024
